Cyclobenzaprine Wikipedia

Cyclobenzaprine Wikipedia

However, caffeine can also cause physical dependence when it is used for a long time. This may lead to withdrawal (rebound) headaches when you stop taking it. Cyclobenzaprine has been compared to Valium (diazepam) and Soma (carisoprodol) in clinical trials. Cyclobenzaprine was similarly effective to these drugs for treating acute low back pain. Robaxin, known by its generic name methocarbamol, was released on the market in the 1960s. While its exact mechanism of action is unknown, Robaxin (learn about Robaxin) is believed to relieve discomfort through its sedative effects.

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The combination of Flexeril and a monoamine oxidase inhibitor (MAOI) can cause a life-threatening drug interaction. This drug interaction can lead to serotonin syndrome, which can include symptoms like abnormally high fever, tremors, increased sweating, nausea, and vomiting. These allergic reactions can manifest as trouble breathing, severe rash, and swelling. Seek immediate medical attention if you experience these adverse effects. Cyclobenzaprine has a higher retail cost of $42.99, compared to Robaxin. Generic cyclobenzaprine tablets are often covered by Medicare and insurance plans.


In a head-to-head trial between methocarbamol and cyclobenzaprine, there was no significant difference in muscle spasms or tenderness. However, patients experienced slightly better improvements in local pain with cyclobenzaprine (48% vs. 40%). Cyclobenzaprine was also found to produce more somnolence or drowsiness (58% vs. 10%). In a small number of people, cyclobenzaprine and methocarbamol can cause more serious adverse effects such as allergic reactions with severe rash, swelling, and trouble breathing.

Up to 80% of adults experience low back pain at some point in their lives. It’s important to thoroughly inform your doctor about all of your medical conditions because muscle relaxants might not be suitable for certain diseases and conditions. Both Zanaflex and Flexeril can interact with drugs that have CNS depressant effects. These types of drugs include barbiturates, opioids, and benzodiazepines. Zanaflex and Flexeril can enhance their effects and lead to increased dizziness and sedation.

Zanaflex (What is Zanaflex?) is the brand name for tizanidine and acts as an alpha-2 adrenergic agonist. It was initially approved in 1996 for the treatment of muscle spasticity. Although its exact mechanism of action is unknown, it is believed to manage muscle spasticity through the inhibition of motor nerve signals. In case of acute cyclobenzaprine overdose, emergency medicine physicians and triage nurses should stabilize the patient. If EKG demonstrates QRS prolongation, the clinician should initiate sodium bicarbonate therapy.

It is not generally recommended to drink alcohol with muscle relaxants. Zanaflex may be harmful to the unborn baby according to animal studies. There have been no adequate animal or human studies that show Flexeril is harmful while pregnant. Muscle relaxers should only be used if there are clear benefits that outweigh potential risks. Seek medical advice from your healthcare provider for treatment options while pregnant. The most common side effects of Flexeril include drowsiness, dry mouth, headache, fatigue, and dizziness.

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In severe overdose, ventricular arrhythmias and seizures may require MICU-level of care under the supervision of a critical care physician. As discussed above, the clinician should consider contacting the poison control center in refractory cases. A psychiatrist consult is required for deliberate poisoning of cyclobenzaprine. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician.

  • In preclinical research, cyclobenzaprine reduced skeletal muscle hyperactivity.
  • It is also believed that Robaxin relaxes the muscle by having depressive effects on the central nervous system.
  • The generic version of Flexeril, cyclobenzaprine, is widely available.
  • A medical detox can help people with a cyclobenzaprine addiction safely undergo withdrawal in a clinically supervised setting.

It is also believed that Robaxin relaxes the muscle by having depressive effects on the central nervous system. Clinicians should monitor for signs and symptoms of serotonin syndrome if the patient is taking other serotonergic drugs. In two case reports, the authors described patients who quickly developed serotonin syndrome after initiating cyclobenzaprine in the short term.

Are Robaxin and Flexeril the same?

Start the journey to recovery today by contacting our team of compassionate counselors. If you’re prescribed cyclobenzaprine by your doctor and experience side effects that interfere with your daily life, contact the physician. Administration of the extended-release capsule with food increased peak plasma concentrations flexeril pill identifier by 35% and systemic exposure by 20%, but did not affect time to peak plasma concentration. Shares the drug interaction potential of tricyclic antidepressants; consider the usual interactions of tricyclic antidepressant therapy. Caffeine is a CNS stimulant that is used with pain relievers to increase their effect.

If you don’t have insurance, you can use a SingleCare discount card to cut this cost to less than $8 depending on your pharmacy. Even if you do have insurance, it may be a good idea to find out if you can get a cheaper price on muscle relaxants. Flexeril (generic name cyclobenzaprine) was developed in the 1970s. Flexeril works on the central nervous system to reduce motor activity or muscle contractions, thus, relieving muscle spasms. Drinking alcohol while taking Zanaflex or Flexeril can enhance the sedative effects of these drugs.

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